• Type of study
• Animals
• Duration of the study

Laser-induced choroidal neovascularization (CNV) model

• Mice or rats

  Approx. 2 months

Intraocular pressure (IOP) measurement

• Normotensive IOP models
   

  beagles or rabbits

  Approx. 1.5 months
   

• Ocular hypertension models

  rats

  Approx. 1.5 months

• Laser-induced ocular hypertension model

  ー

  Approx. 1.5 months

• Water loading-induced ocular hypertension model

  Rabbits
   

  Approx. 1.5 months
   

Water loading-induced retinal ischemia model

• Rats

  Approx. 3 months

Light-induced retinal degeneration model

• Rats

  Approx. 3 months

Dry eye model

• Rabbits
   

  Approx. 1.5 months
  (winter only)

Bioequivalency tests (ophthalmic solutions, etc.)

• －

  －

Efficacy studies of cosmetics/beauty equipment
※Studies measuring TEWL and those using skin surface hygrometers and sebumeters are also available.

• Whitening studies

  Brown guinea pigs

  Approx. 2.5 months

• Wrinkle-improving studies

  Hairless mice (wrinkle model)

  Approx. 6 months

• UV light-induced skin stress inhibitory studies

  Brown guinea pigs
   

  Approx. 3 months
   

• Hair growth studies

  C3H mice

  Approx. 3 months

• Rough skin studies

  Mice (rough skin model)

  Approx. 2 months

Efficacy studies of food

• Efficacy studies for obesity

  Zucker rats (obesity model), etc.

  ―

• Palatability studies of pet food

  Dogs or cats

  Long term only

In addition to these studies, LSL challenges various studies. Please feel free to consult us.

• Type of study
• Number of subjects
• Duration of the study

Human patch test(24/48 hours)

• 20/40

  Approx. 1 month

Moisture test

• 8 or more

  Approx. 1 month

Stinging test(for labeling of cosmetics)

• 6

  Approx. 1 month

Sensory analysis

• 5

  ―

※Please consult us for other usage tests, sensory analysis, etc.
※Please feel free to consult us regarding details, costs and duration of the studies (free quotation)

• Type of study
• Animals/bacterial strains/cells
• Duration of the study

Single dose toxicity studies
※Please consult us regarding the route of administration (percutaneous, intravenous, etc.).

• Single dose level (2000 mg/kg) studies (limit tests)

  Mice or rats (≥5/sex)
   

  Approx. 1 month
   

• Dose range finding studies (OECD Guideline)

  Mice or rats (≥5/sex/group)
   

  Approx. 1.5 months
   

• Dose range finding studies (for pesticide registration)

  Quails (≥5/sex/group)
   

  Approx. 1.5 months
   

Repeated oral dose toxicity studies
※Please consult us regarding the duration of the study and dose levels (number of groups).

• Mice or rats (≥5/sex/group)

  At least 3 months

Primary skin irritation studies

• Rabbits (≥3)

  Approx. 1 month

Cumulative skin irritation studies(14-day continuous application)

• Guinea pigs or rabbits (≥3)

  Approx. 1.5 months

Phototoxicity studies(Morikawa’s method）

• Guinea pigs (≥5)

  Approx. 1 month

Skin sensitization studies(Maximization Test/Adjuvant and Patch Test/Buehler Test)

• Guinea pigs (≥5/group)

  Approx. 2 months

Photosensitization studies(Adjuvant and Strip Test)

• Guinea pigs (≥5/group)

  Approx. 2 months

Mucosal irritation studies

• Rabbits or guinea pigs

  Approx. 3 months

Eye irritation studies

• Rabbits

  Approx. 3 months

Genotoxicity studies

• Ames tests (bacterial reverse mutation tests)

  5 bacterial strains
   

  Approx. 1 month
   

• Chromosomal aberration tests

  Cultured Chinese hamster cells

  Approx. 3 months

• Micronucleus tests

  Mice or rats

  Approx. 2 months

• Cytotoxicity studies

  V79 cells (JCRB0603)

  Approx. 1 month

• Ichthyotoxicity studies

  Japanese rice fish (7/group)

  Approx. 1 month

Please feel free to consult us regarding details, costs, etc. of the studies (free quotation).